Page 7 - Genetics_From_Genes_to_Genomes_6th_FULL_Part1

vi Contents

PART II PART III

What Genes Are and What Analysis of Genetic
They Do 181 Information 316

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chapter 6 chapter 9

DNA Structure, Replication, and Digital Analysis of DNA 316
Recombination 181
9.1 Fragmenting DNA 317
6.1 Experimental Evidence for DNA as the Genetic 9.2 Cloning DNA Fragments 322
Material 182
6.2 The Watson and Crick Double Helix Model of 9.3 Sequencing DNA 327
DNA 187 9.4 Sequencing Genomes 330
6.3 Genetic Information in Nucleotide ■ Tools of Genetics: Serendipity in Science: The
Sequence 193 Discovery of Restriction Enzymes 319
6.4 DNA Replication 194
6.5 Homologous Recombination at the DNA chapter 10
Level 201 Genome Annotation 341
6.6 Site-Specific Recombination 209 10.1 Finding the Genes in Genomes 342
chapter 7 10.2 Genome Architecture and Evolution 347
10.3 Bioinformatics: Information Technology and
Anatomy and Function of a Gene: Dissection Genomes 354
Through Mutation 219 10.4 A Comprehensive Example: The Hemoglobin
7.1 Mutations: Primary Tools of Genetic Genes 355
Analysis 220
7.2 Molecular Mechanisms That Alter DNA chapter 11
Sequence 225 Analyzing Genomic Variation 365
7.3 DNA Repair Mechanisms 234
7.4 What Mutations Tell Us About Gene 11.1 Variation Among Genomes 366
Structure 239 11.2 Genotyping a Known Disease-Causing
7.5 What Mutations Tell Us About Gene Mutation 371
Function 247 11.3 Sampling DNA Variation in a Genome 376
7.6 A Comprehensive Example: Mutations That 11.4 Positional Cloning 380
Affect Vision 255 11.5 The Era of Whole-Genome Sequencing 386
■ Tools of Genetics: The Lod Score Statistic 384
■ Fast Forward: Trinucleotide Repeat Diseases:
Huntington Disease and Fragile X Syndrome 229
PART IV
chapter 8
Gene Expression: The Flow of Information from How Genes Travel on
DNA to RNA to Protein 270 Chromosomes 406
8.1 The Genetic Code 271
8.2 Transcription: From DNA to RNA 280
8.3 Translation: From mRNA to Protein 289 (left) © Texas A&M University/AP Photo;
(right) © Alpha/ZUMAPRESS/Newscom
8.4 Differences in Gene Expression Between
Prokaryotes and Eukaryotes 297 chapter 12
8.5 The Effects of Mutations on Gene Expression The Eukaryotic Chromosome 406
and Function 299
12.1 Chromosomal DNA and Proteins 407
■ Genetics and Society: HIV and Reverse 12.2 Chromosome Structure and Compaction 408
Transcription 284