Page 12 - Genetics_From_Genes_to_Genomes_6th_FULL_Part1

Changes in the 6th Edition:

A Chapter-by-Chapter Summary

The sixth edition has been revised and modernized signifi- Chapter 9 Digital Analysis of DNA
cantly as compared with the fifth edition. We scrutinized the ∙ Improved depiction of plasmid cloning vectors.
entire text and clarified the language wherever possible. In ∙ Renovated explanation of paired-end whole-genome
total, we created more than 50 new Figures and Tables, and shotgun sequencing.
revised more than 100 in addition. We also wrote more than Chapter 10 Genome Annotation
125 new end-of-chapter problems, and revised many other ∙ Improved depiction of alternative RNA splicing.
problems for clarity. The entire Solutions Manual and Study ∙ New illustration of consensus amino acid sequences
Guide was corrected and revised for clarity. We added sev- in proteins.
eral new Fast Forward, Genetics and Society, and Tools of ∙ New material on the evolution of de novo genes.
Genetics Boxes on modern topics. Chapter 9 in the 5th edi-
tion was split into two separate chapters in the 6th edition: Chapter 12 The Eukaryotic Chromosome
Chapter 9 (Digital Analysis of DNA) and Chapter 10 ∙ New material on synthetic yeast chromosomes.
(Genome Annotation). Chapter 15 Organellar Inheritance
∙ New Fast Forward Box about the Mitchondrial Eve
Along with the numerous text changes, the authors have concept.
also spent a great deal of time updating the test bank and
question bank content to align more closely to the text. Chapter 17 Gene Regulation in Eukaryotes
There will also be new video tutorials for difficult concepts ∙ New Tools of Genetics Box: The Gal4/UAS G Binary
in every chapter! Gene Expression System
∙ New part of Epigenetics section: Can
Every chapter of the sixth edition was improved signifi- Environmentally Acquired Traits Be Inherited?
cantly from the fifth edition. The most important changes in ∙ New part of Regulation After Transcription section:
the sixth edition are summarized below: Trans-acting Proteins Regulate Translation
Chapter 3 Extensions to Mendel’s Laws Chapter 18 Manipulating the Genomes of Eukaryotes
∙ Relationship between epistasis and complementation ∙ New part of Targeted Mutagenesis section: CRISPR/
explained more clearly. Cas9 Allows Targeted Gene Editing in Any Organism
∙ Discussion of two-gene versus multifactorial ∙ New Tools of Genetics Box: How Bacteria Vaccinate
inheritance now separated for clarity. Themselves Against Viral Infections with CRISPR/Cas9
∙ Comprehensive Example about dog coat colors ∙ New Genetics and Society Box: Should We Alter the
expanded to include molecular explanations for the Genomes of Human Germ Lines?
various gene activities. Chapter 19 The Genetic Analysis of Development
Chapter 4 The Chromosome Theory of Inheritance ∙ Comprehensive Example of Drosophila body
∙ Figures and text altered to clarify that each chromatid patterning revised to clarify that homeotic genes
has a centromere. function within parasegments, and to clarify the
∙ New Fast Forward Box: Visualizing X Chromosome concept of a morphogen.
Inactivation in Transgenic Mice Chapter 20 The Genetics of Cancer
Chapter 5 Linkage, Recombination, and the Mapping of ∙ Clarified the fact that mutation drives cancer
Genes on Chromosomes progression.
∙ New Fast Forward Box: Mapping the Crossovers that ∙ Improved explanation of driver and passenger mutations.
Generate Individual Human Sperm ∙ Increased coverage of tumor genome sequencing and
the heterogeneity of mutations in different individuals
Chapter 6 DNA Structure, Replication, and Recombination with cancers in the same organ.
∙ Improvements to diagrams of DSB repair model of
recombination. Chapter 22 The Genetics of Complex Traits
∙ Revised the section on heritability to clarify: lines of
∙ New section about site-specific recombination.
correlation and correlation coefficients; how to use
Chapter 7 Anatomy and Function of Gene: Dissection different kinds of human twin studies to estimate the
Through Mutation heritability of complex quantitative traits and complex
∙ Reorganized and clarified material to separate the discrete traits.
discussion of DNA sequence alteration mechanisms ∙ New explanation of how to use the chi-square test for
from DNA repair mechanisms. independence for GWAS.
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