Page 6 - Genetics_From_Genes_to_Genomes_6th_FULL_Part1

Contents

About the Authors iii chapter 4
Preface ix The Chromosome Theory of Inheritance 89
Acknowledgements xx
4.1 Chromosomes: The Carriers of Genes 90
Introduction: Genetics in the 4.2 Sex Chromosomes and Sex
Twenty-First Century 1 Determination 94
4.3 Mitosis: Cell Division That Preserves
chapter 1 Chromosome Number 98
Genetics: The Study of Biological Information 1 4.4 Meiosis: Cell Divisions That Halve
Chromosome Number 103
1.1 DNA: Life’s Fundamental Information
Molecule 2 4.5 Gametogenesis 109
1.2 Proteins: The Functional Molecules of Life 4.6 Validation of the Chromosome
Processes 3 Theory 113
1.3 Molecular Similarities of All Life-Forms 4 4.7 Sex-Linked and Sexually Dimorphic Traits in
1.4 The Modular Construction of Genomes 6 Humans 118
1.5 Modern Genetic Techniques 8 ■ Genetics and Society: Prenatal Genetic
Diagnosis 93
1.6 Human Genetics and Society 10
■ Fast Forward: Transgenic Mice Prove That SRY Is
the Maleness Factor 96
PART I
■ Fast Forward: Visualizing X Chromosome
Basic Principles: Inactivation in Transgenic Mice 121
How Traits Are
Transmitted 14 chapter 5
Linkage, Recombination, and the Mapping of
© Lawrence Manning/Corbis RF Genes on Chromosomes 133
chapter 2 5.1 Gene Linkage and Recombination 134
5.2 Recombination: A Result of Crossing-Over
Mendel’s Principles of Heredity 14
During Meiosis 138
2.1 The Puzzle of Inheritance 15 5.3 Mapping: Locating Genes Along a
2.2 Genetic Analysis According to Mendel 20 Chromosome 143
2.3 Mendelian Inheritance in Humans 30 5.4 The Chi-Square Test and Linkage
■ Genetics and Society: Developing Guidelines for Analysis 153
Genetic Screening 34 5.5 Tetrad Analysis in Fungi 156
5.6 Mitotic Recombination and Genetic
chapter 3 Mosaics 164

Extensions to Mendel’s Laws 45 ■ Fast Forward: Mapping the Crossovers that
Generate the Chromosomes of Individual Human
3.1 Extensions to Mendel for Single-Gene Sperm 150
Inheritance 46
3.2 Extensions to Mendel for Two-Gene ■ Fast Forward: Gene Mapping May Lead to a Cure
for Cystic Fibrosis 152
Inheritance 55
3.3 Extensions to Mendel for Multifactorial ■ Tools of Genetics: The Chi-Square Test for
Goodness of Fit 155
Inheritance 68
■ Genetics and Society: Mitotic Recombination and
■ Genetics and Society: Disease Prevention Versus Cancer Formation 167
the Right to Privacy 72

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